Saturday 22 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h00 |   SV Wehen vs Bayer Leverkusen | 0 - 4 | DFB Pokal Stage : Round of 64 | BRITA-Arena |
Saturday 29 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  SV Elversberg vs Bayer Leverkusen | 3 - 2 | Bundesliga Stage : MD1 | Waldstadion Kaiserlinde |
Saturday 5 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Bayer Leverkusen vs Union Berlin | 4 - 0 | Bundesliga Stage : MD2 | BayArena |
Saturday 12 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  FC Augsburg vs Bayer Leverkusen | - | Bundesliga Stage : MD3 | WWK Arena |
Wednesday 16 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Bayer Leverkusen vs Celje | - | UEFA Europa League Stage : League phase Matchday 1 | BayArena |
Sunday 20 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Bayer Leverkusen vs RB Leipzig | - | Bundesliga Stage : MD4 | BayArena |
Saturday 10 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  FSV Mainz 05 vs Bayer Leverkusen | - | Bundesliga Stage : MD5 | Mewa Arena |
Thursday 15 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h45 |  Lech Poznan vs Bayer Leverkusen | - | UEFA Europa League Stage : League phase Matchday 2 | Stadion Poznan |
Saturday 17 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Bayer Leverkusen vs SC Freiburg | - | Bundesliga Stage : MD6 | BayArena |
Thursday 22 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h45 |  OFI vs Bayer Leverkusen | - | UEFA Europa League Stage : League phase Matchday 3 | Pankritio Stadium |
Saturday 24 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  1899 Hoffenheim vs Bayer Leverkusen | - | Bundesliga Stage : MD7 | PreZero Arena |
Tuesday 27 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Bayer Leverkusen vs 1. FC Nürnberg | - | DFB Pokal Stage : Round of 32 | BayArena |
Saturday 31 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Bayer Leverkusen vs VfB Stuttgart | - | Bundesliga Stage : MD8 | BayArena |
Thursday 5 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Bayer Leverkusen vs Marseille | - | UEFA Europa League Stage : League phase Matchday 4 | BayArena |
Saturday 7 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  1. FC Köln vs Bayer Leverkusen | - | Bundesliga Stage : MD9 | RheinEnergieStadion |
Saturday 21 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Bayer Leverkusen vs SC Paderborn 07 | - | Bundesliga Stage : MD10 | BayArena |
Thursday 26 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 18h45 |  Dinamo Zagreb vs Bayer Leverkusen | - | UEFA Europa League Stage : League phase Matchday 5 | Stadion Maksimir |
Saturday 28 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Borussia Dortmund vs Bayer Leverkusen | - | Bundesliga Stage : MD11 | Signal Iduna Park |
Saturday 5 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Bayer Leverkusen vs Borussia Mönchengladbach | - | Bundesliga Stage : MD12 | BayArena |
Thursday 10 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Bayer Leverkusen vs Beşiktaş | - | UEFA Europa League Stage : League phase Matchday 6 | BayArena |
Saturday 12 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Werder Bremen vs Bayer Leverkusen | - | Bundesliga Stage : MD13 | Weserstadion |
Saturday 19 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Bayer Leverkusen vs Eintracht Frankfurt | - | Bundesliga Stage : MD14 | BayArena |
Saturday 9 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Hamburger SV vs Bayer Leverkusen | - | Bundesliga Stage : MD15 | Volksparkstadion |
Tuesday 12 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h30 |  Bayern München vs Bayer Leverkusen | - | Bundesliga Stage : MD16 | Allianz Arena |
Saturday 16 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Bayer Leverkusen vs FC Schalke 04 | - | Bundesliga Stage : MD17 | BayArena |
Thursday 21 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Bayer Leverkusen vs Red Bull Salzburg | - | UEFA Europa League Stage : League phase Matchday 7 | BayArena |
Saturday 23 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | Bayer Leverkusen vs SV Elversberg | - | Bundesliga Stage : MD18 | BayArena |
Thursday 28 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Lyon vs Bayer Leverkusen | - | UEFA Europa League Stage : League phase Matchday 8 | Parc Olympique Lyonnais |
Saturday 30 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | Union Berlin vs Bayer Leverkusen | - | Bundesliga Stage : MD19 | - |
Saturday 6 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | Bayer Leverkusen vs FC Augsburg | - | Bundesliga Stage : MD20 | BayArena |
Saturday 13 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | RB Leipzig vs Bayer Leverkusen | - | Bundesliga Stage : MD21 | Red Bull Arena |
Saturday 20 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | Bayer Leverkusen vs FSV Mainz 05 | - | Bundesliga Stage : MD22 | BayArena |
Saturday 27 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | SC Freiburg vs Bayer Leverkusen | - | Bundesliga Stage : MD23 | Europa-Park Stadion |
Tuesday 2 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h30 | Bayer Leverkusen vs 1899 Hoffenheim | - | Bundesliga Stage : MD24 | BayArena |
Saturday 6 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | VfB Stuttgart vs Bayer Leverkusen | - | Bundesliga Stage : MD25 | MHPArena |
Saturday 13 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | Bayer Leverkusen vs 1. FC Köln | - | Bundesliga Stage : MD26 | BayArena |
Saturday 20 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 | SC Paderborn 07 vs Bayer Leverkusen | - | Bundesliga Stage : MD27 | Home Deluxe Arena |
Saturday 3 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Bayer Leverkusen vs Borussia Dortmund | - | Bundesliga Stage : MD28 | BayArena |
Saturday 10 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Borussia Mönchengladbach vs Bayer Leverkusen | - | Bundesliga Stage : MD29 | Borussia-Park |
Saturday 17 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Bayer Leverkusen vs Werder Bremen | - | Bundesliga Stage : MD30 | BayArena |
Saturday 24 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Eintracht Frankfurt vs Bayer Leverkusen | - | Bundesliga Stage : MD31 | Deutsche Bank Park |
Saturday 8 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Bayer Leverkusen vs Hamburger SV | - | Bundesliga Stage : MD32 | BayArena |
Saturday 15 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Bayer Leverkusen vs Bayern München | - | Bundesliga Stage : MD33 | BayArena |
Saturday 22 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | FC Schalke 04 vs Bayer Leverkusen | - | Bundesliga Stage : MD34 | Veltins Arena |