Tuesday 4 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |   Sparta Praha vs Lyon | 2 - 1 | UEFA Champions League Stage : Round 3rd Qualifying | Pragues Letna Hill |
Tuesday 11 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | Lyon vs Sparta Praha | 3 - 0 | UEFA Champions League Stage : Round 3rd Qualifying | Groupama Stadium |
Tuesday 18 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Fenerbahçe vs Lyon | 1 - 1 | UEFA Champions League Stage : Play-offs | Chobani Stadium |
Saturday 22 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Toulouse vs Lyon | 0 - 2 | Ligue 1 Stage : MD1 | Stadium Municipal |
Wednesday 26 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | Lyon vs Fenerbahçe | 1 - 2 | UEFA Champions League Stage : Play-offs | Groupama Stadium |
Saturday 29 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Lyon vs Le Havre | 1 - 1 | Ligue 1 Stage : MD2 | Groupama Stadium |
Friday 4 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 18h00 |  Lyon vs Auxerre | 3 - 1 | Ligue 1 Stage : MD3 | Groupama Stadium |
Saturday 12 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Paris FC vs Lyon | 0 - 0 | Ligue 1 Stage : MD4 | Stade Jean Bouin |
Wednesday 16 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Anderlecht vs Lyon | 1 - 2 | UEFA Europa League Stage : League phase Matchday 1 | Lotto Park |
Saturday 19 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Lyon vs Rennes | 4 - 0 | Ligue 1 Stage : MD5 | Groupama Stadium |
Friday 9 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Lens vs Lyon | - | Ligue 1 Stage : MD6 | Stade Bollaert-Delelis |
Thursday 15 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h45 |  Lyon vs Crystal Palace | - | UEFA Europa League Stage : League phase Matchday 2 | Parc Olympique Lyonnais |
Sunday 18 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Lyon vs Nice | - | Ligue 1 Stage : MD7 | Groupama Stadium |
Thursday 22 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  1899 Hoffenheim vs Lyon | - | UEFA Europa League Stage : League phase Matchday 3 | SNP Arena |
Sunday 25 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Paris Saint Germain vs Lyon | - | Ligue 1 Stage : MD8 | Parc des Princes |
Saturday 31 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Lyon vs Angers | - | Ligue 1 Stage : MD9 | Groupama Stadium |
Thursday 5 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 18h45 |  Real Sociedad vs Lyon | - | UEFA Europa League Stage : League phase Matchday 4 | Anoeta |
Sunday 8 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h15 |  Stade Brestois 29 vs Lyon | - | Ligue 1 Stage : MD10 | Stade Francis-Le-Blé |
Saturday 21 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Lille vs Lyon | - | Ligue 1 Stage : MD11 | Stade Pierre-Mauroy |
Thursday 26 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Lyon vs Lillestrom | - | UEFA Europa League Stage : League phase Matchday 5 | Parc Olympique Lyonnais |
Sunday 29 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Lyon vs Monaco | - | Ligue 1 Stage : MD12 | Groupama Stadium |
Saturday 5 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 |  Estac Troyes vs Lyon | - | Ligue 1 Stage : MD13 | Stade de l'Aube |
Thursday 10 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Lyon vs Union St. Gilloise | - | UEFA Europa League Stage : League phase Matchday 6 | Parc Olympique Lyonnais |
Sunday 13 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Lyon vs Marseille | - | Ligue 1 Stage : MD14 | Parc Olympique Lyonnais |
Saturday 2 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 |  Le Mans vs Lyon | - | Ligue 1 Stage : MD15 | MMArena |
Saturday 16 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 |  Lyon vs Lorient | - | Ligue 1 Stage : MD16 | Groupama Stadium |
Thursday 21 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 18h45 |  Jagiellonia vs Lyon | - | UEFA Europa League Stage : League phase Matchday 7 | Chorten Arena |
Saturday 23 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 |  Strasbourg vs Lyon | - | Ligue 1 Stage : MD17 | Stade de la Meinau |
Thursday 28 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Lyon vs Bayer Leverkusen | - | UEFA Europa League Stage : League phase Matchday 8 | Parc Olympique Lyonnais |
Saturday 30 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Lyon vs Lille | - | Ligue 1 Stage : MD18 | Groupama Stadium |
Saturday 6 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Rennes vs Lyon | - | Ligue 1 Stage : MD19 | Roazhon Park |
Saturday 13 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Lyon vs Lens | - | Ligue 1 Stage : MD20 | Groupama Stadium |
Saturday 20 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Le Havre vs Lyon | - | Ligue 1 Stage : MD21 | Stade Océane |
Saturday 27 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Lyon vs Toulouse | - | Ligue 1 Stage : MD22 | Groupama Stadium |
Saturday 6 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Monaco vs Lyon | - | Ligue 1 Stage : MD23 | Stade Louis II |
Saturday 13 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Lyon vs Estac Troyes | - | Ligue 1 Stage : MD24 | Groupama Stadium |
Sunday 21 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 | Marseille vs Lyon | - | Ligue 1 Stage : MD25 | - |
Saturday 3 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Nice vs Lyon | - | Ligue 1 Stage : MD26 | Allianz Riviera |
Saturday 10 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Lyon vs Strasbourg | - | Ligue 1 Stage : MD27 | Groupama Stadium |
Saturday 17 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Angers vs Lyon | - | Ligue 1 Stage : MD28 | Stade Raymond-Kopa |
Saturday 24 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Lyon vs Stade Brestois 29 | - | Ligue 1 Stage : MD29 | Groupama Stadium |
Saturday 1 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Auxerre vs Lyon | - | Ligue 1 Stage : MD30 | Stade de l'Abbé-Deschamps |
Sunday 9 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 | Lyon vs Paris Saint Germain | - | Ligue 1 Stage : MD31 | Parc Olympique Lyonnais |
Sunday 16 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Lyon vs Le Mans | - | Ligue 1 Stage : MD32 | Groupama Stadium |
Saturday 22 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Lorient vs Lyon | - | Ligue 1 Stage : MD33 | Stade du Moustoir |
Saturday 29 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | Lyon vs Paris FC | - | Ligue 1 Stage : MD34 | Groupama Stadium |
