Sunday 22 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 4h30 |   San Diego vs CF Montreal | 5 - 0 | Major League Soccer Stage : MD1 | Snapdragon Stadium |
Monday 2 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h15 |  San Diego vs St. Louis City | 2 - 0 | Major League Soccer Stage : MD2 | Snapdragon Stadium |
Sunday 8 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  Sporting Kansas City vs San Diego | 0 - 1 | Major League Soccer Stage : MD3 | Children's Mercy Park |
Sunday 15 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 1h30 |  FC Dallas vs San Diego | 3 - 3 | Major League Soccer Stage : MD4 | Toyota Stadium |
Monday 23 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 0h00 |  San Diego vs Real Salt Lake | 2 - 2 | Major League Soccer Stage : MD5 | Snapdragon Stadium |
Sunday 5 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs San Diego | 3 - 0 | Major League Soccer Stage : MD6 | PayPal Park |
Sunday 12 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 |  San Diego vs Minnesota United FC | 1 - 2 | Major League Soccer Stage : MD7 | Snapdragon Stadium |
Sunday 19 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 | Real Salt Lake vs San Diego | 4 - 2 | Major League Soccer Stage : MD8 | Rio Tinto Stadium |
Thursday 23 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 1h30 |  Houston Dynamo vs San Diego | 1 - 0 | Major League Soccer Stage : MD9 | Shell Energy Stadium |
Sunday 26 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  San Diego vs Portland Timbers | 1 - 2 | Major League Soccer Stage : MD10 | Snapdragon Stadium |
Sunday 3 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  San Diego vs Los Angeles FC | 2 - 2 | Major League Soccer Stage : MD11 | Snapdragon Stadium |
Sunday 10 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 |  Seattle Sounders vs San Diego | 1 - 1 | Major League Soccer Stage : MD12 | Lumen Field |
Thursday 14 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  San Diego vs Austin | 5 - 0 | Major League Soccer Stage : MD13 | Snapdragon Stadium |
Sunday 17 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  San Diego vs FC Cincinnati | 3 - 3 | Major League Soccer Stage : MD14 | Snapdragon Stadium |
Sunday 24 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  San Diego vs Vancouver Whitecaps | 2 - 4 | Major League Soccer Stage : MD15 | Snapdragon Stadium |
Thursday 23 July
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 |  Colorado Rapids vs San Diego | 1 - 0 | Major League Soccer Stage : MD16 | Dick's Sporting Goods Park |
Sunday 26 July
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h30 | San Diego vs FC Dallas | 1 - 0 | Major League Soccer Stage : MD17 | Snapdragon Stadium |
Sunday 2 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 1h30 | Minnesota United FC vs San Diego | 1 - 1 | Major League Soccer Stage : MD18 | Allianz Field |
Sunday 16 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | Los Angeles FC vs San Diego | 0 - 1 | Major League Soccer Stage : MD19 | BMO Stadium |
Thursday 20 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | Portland Timbers vs San Diego | 3 - 1 | Major League Soccer Stage : MD20 | Providence Park |
Sunday 23 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | San Diego vs Colorado Rapids | 3 - 0 | Major League Soccer Stage : MD21 | Snapdragon Stadium |
Sunday 30 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 |  San Diego vs Los Angeles Galaxy | 3 - 1 | Major League Soccer Stage : MD22 | Snapdragon Stadium |
Sunday 6 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 0h30 |  Orlando City SC vs San Diego | 1 - 0 | Major League Soccer Stage : MD23 | Exploria Stadium |
Thursday 10 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | San Diego vs San Jose Earthquakes | 2 - 3 | Major League Soccer Stage : MD24 | Snapdragon Stadium |
Monday 14 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 2h00 |  San Diego vs Philadelphia Union | - | Major League Soccer Stage : MD25 | Snapdragon Stadium |
Monday 21 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 0h00 |  Inter Miami vs San Diego | - | Major League Soccer Stage : MD26 | Nu Stadium |
Sunday 27 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 1h30 | Austin vs San Diego | - | Major League Soccer Stage : MD27 | Q2 Stadium |
Sunday 11 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 0h30 |  New York Red Bulls vs San Diego | - | Major League Soccer Stage : MD28 | Sports Illustrated Stadium |
Thursday 15 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | San Diego vs Houston Dynamo | - | Major League Soccer Stage : MD29 | Snapdragon Stadium |
Sunday 18 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | Los Angeles Galaxy vs San Diego | - | Major League Soccer Stage : MD30 | Dignity Health Sports Park |
Sunday 25 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | San Diego vs Seattle Sounders | - | Major League Soccer Stage : MD31 | Snapdragon Stadium |
Thursday 29 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 3h30 | Vancouver Whitecaps vs San Diego | - | Major League Soccer Stage : MD32 | BC Place |
Saturday 31 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | St. Louis City vs San Diego | - | Major League Soccer Stage : MD33 | CITYPARK |
Sunday 8 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 1h00 | San Diego vs Sporting Kansas City | - | Major League Soccer Stage : MD34 | Snapdragon Stadium |