Sunday 16 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 |   Watford vs Southampton | 2 - 1 | Championship Stage : MD1 | Vicarage Road |
Saturday 22 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  Southampton vs Stoke City | 3 - 1 | Championship Stage : MD2 | St. Mary's Stadium |
Saturday 29 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  Southampton vs Millwall | 5 - 1 | Championship Stage : MD3 | St. Mary's Stadium |
Tuesday 1 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Birmingham vs Southampton | 1 - 1 | Championship Stage : MD4 | St. Andrew's @ Knighthead Park |
Saturday 5 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h30 |  Lincoln vs Southampton | 1 - 1 | Championship Stage : MD5 | Sincil Bank |
Tuesday 8 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Southampton vs Swansea | 3 - 1 | Championship Stage : MD6 | - |
Saturday 12 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  Southampton vs Bristol City | - | Championship Stage : MD7 | - |
Saturday 19 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  Wrexham vs Southampton | - | Championship Stage : MD8 | Racecourse Ground |
Sunday 11 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h00 |  Southampton vs Portsmouth | - | Championship Stage : MD9 | - |
Wednesday 14 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 |  Norwich vs Southampton | - | Championship Stage : MD10 | Carrow Road |
Saturday 17 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  Southampton vs Bolton | - | Championship Stage : MD11 | - |
Saturday 24 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 |  West Ham vs Southampton | - | Championship Stage : MD12 | London Stadium |
Saturday 31 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Southampton vs QPR | - | Championship Stage : MD13 | - |
Tuesday 3 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  West Brom vs Southampton | - | Championship Stage : MD14 | The Hawthorns |
Saturday 7 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Preston vs Southampton | - | Championship Stage : MD15 | Deepdale |
Saturday 21 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 |  Southampton vs Derby | - | Championship Stage : MD16 | - |
Tuesday 24 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 |  Sheffield Utd vs Southampton | - | Championship Stage : MD17 | Bramall Lane |
Friday 27 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Southampton vs Middlesbrough | - | Championship Stage : MD18 | - |
Saturday 5 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Wolves vs Southampton | - | Championship Stage : MD19 | Molineux Stadium |
Wednesday 9 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Southampton vs Burnley | - | Championship Stage : MD20 | - |
Saturday 12 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Cardiff vs Southampton | - | Championship Stage : MD21 | Cardiff City Stadium |
Saturday 19 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Southampton vs Blackburn | - | Championship Stage : MD22 | - |
Saturday 26 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 |  Charlton vs Southampton | - | Championship Stage : MD23 | The Valley |
Tuesday 29 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h15 | Southampton vs West Ham | - | Championship Stage : MD24 | - |
Friday 1 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Southampton vs Cardiff | - | Championship Stage : MD25 | - |
Saturday 16 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Bolton vs Southampton | - | Championship Stage : MD26 | Toughsheet Community Stadium |
Saturday 23 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | QPR vs Southampton | - | Championship Stage : MD27 | Loftus Road |
Tuesday 26 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 | Southampton vs West Brom | - | Championship Stage : MD28 | - |
Saturday 30 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Southampton vs Preston | - | Championship Stage : MD29 | - |
Saturday 6 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Derby vs Southampton | - | Championship Stage : MD30 | Pride Park |
Saturday 13 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Bristol City vs Southampton | - | Championship Stage : MD31 | Ashton Gate Stadium |
Wednesday 17 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 | Southampton vs Norwich | - | Championship Stage : MD32 | - |
Saturday 20 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Southampton vs Wrexham | - | Championship Stage : MD33 | - |
Sunday 28 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h00 | Portsmouth vs Southampton | - | Championship Stage : MD34 | Fratton Park |
Wednesday 3 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 | Stoke City vs Southampton | - | Championship Stage : MD35 | Bet365 Stadium |
Saturday 6 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Southampton vs Watford | - | Championship Stage : MD36 | - |
Saturday 13 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Middlesbrough vs Southampton | - | Championship Stage : MD37 | Riverside Stadium |
Tuesday 16 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h45 | Southampton vs Wolves | - | Championship Stage : MD38 | - |
Saturday 20 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Southampton vs Charlton | - | Championship Stage : MD39 | - |
Saturday 3 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 | Blackburn vs Southampton | - | Championship Stage : MD40 | Ewood Park |
Tuesday 6 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 | Swansea vs Southampton | - | Championship Stage : MD41 | Swansea.com Stadium |
Saturday 10 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 | Southampton vs Lincoln | - | Championship Stage : MD42 | - |
Saturday 17 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 | Millwall vs Southampton | - | Championship Stage : MD43 | The Den |
Tuesday 20 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h45 | Southampton vs Birmingham | - | Championship Stage : MD44 | - |
Saturday 24 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h00 | Burnley vs Southampton | - | Championship Stage : MD45 | Turf Moor |
Saturday 1 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h30 | Southampton vs Sheffield Utd | - | Championship Stage : MD46 | - |