Thursday 23 July
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |   Twente vs Ferencvarosi TC | 1 - 2 | UEFA Europa League Stage : Round 2nd Qualifying | De Grolsch Veste |
Thursday 30 July
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h30 | Ferencvarosi TC vs Twente | 2 - 2 | UEFA Europa League Stage : Round 2nd Qualifying | Groupama Aréna |
Thursday 6 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |  Twente vs Dunajska Streda | 6 - 0 | UEFA Conference League Stage : Round 3rd Qualifying | De Grolsch Veste |
Sunday 9 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h45 |  Heerenveen vs Twente | 1 - 0 | Eredivisie Stage : MD1 | Abe Lenstra Stadion |
Thursday 13 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 18h00 | Dunajska Streda vs Twente | 3 - 3 | UEFA Conference League Stage : Round 3rd Qualifying | MOL Arena |
Sunday 16 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 |  Twente vs PEC Zwolle | 3 - 1 | Eredivisie Stage : MD2 | De Grolsch Veste |
Thursday 20 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |  Twente vs Qarabag | 0 - 1 | UEFA Conference League Stage : Play-offs | De Grolsch Veste |
Thursday 27 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Qarabag vs Twente | 1 - 4 | UEFA Conference League Stage : Play-offs | Tofiq Bahramov Stadium |
Sunday 30 August
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |  Cambuur vs Twente | 1 - 4 | Eredivisie Stage : MD4 | Kooi Stadion |
Sunday 6 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 11h15 |  Groningen vs Twente | 2 - 2 | Eredivisie Stage : MD5 | Euroborg |
Wednesday 9 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h45 |  Twente vs Telstar | 1 - 0 | Eredivisie Stage : MD3 | De Grolsch Veste |
Saturday 12 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 15h30 |  Twente vs ADO Den Haag | 2 - 0 | Eredivisie Stage : MD6 | De Grolsch Veste |
Sunday 20 September
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 |  Twente vs PSV Eindhoven | - | Eredivisie Stage : MD7 | De Grolsch Veste |
Saturday 10 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |  Fortuna Sittard vs Twente | - | Eredivisie Stage : MD8 | Fortuna Sittard Stadion |
Thursday 15 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Twente vs FC Thun | - | UEFA Conference League Stage : League phase Matchday 1 | De Grolsch Veste |
Sunday 18 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 19h00 |  Twente vs Utrecht | - | Eredivisie Stage : MD9 | De Grolsch Veste |
Thursday 22 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  Lincoln Red Imps FC vs Twente | - | UEFA Conference League Stage : League phase Matchday 2 | Europa Point Stadium |
Sunday 25 October
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  AZ Alkmaar vs Twente | - | Eredivisie Stage : MD10 | AFAS Stadion |
Sunday 1 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Excelsior vs Twente | - | Eredivisie Stage : MD11 | Stadion Woudestein |
Thursday 5 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Twente vs Pafos | - | UEFA Conference League Stage : League phase Matchday 3 | De Grolsch Veste |
Sunday 8 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Twente vs Ajax | - | Eredivisie Stage : MD12 | De Grolsch Veste |
Sunday 22 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h15 |  Twente vs Willem II | - | Eredivisie Stage : MD13 | De Grolsch Veste |
Thursday 26 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  SC Freiburg vs Twente | - | UEFA Conference League Stage : League phase Matchday 4 | Europa-Park Stadion |
Sunday 29 November
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 |  NEC Nijmegen vs Twente | - | Eredivisie Stage : MD14 | Goffertstadion |
Sunday 6 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  GO Ahead Eagles vs Twente | - | Eredivisie Stage : MD15 | De Adelaarshorst |
Thursday 10 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Aarhus vs Twente | - | UEFA Conference League Stage : League phase Matchday 5 | Cepheus Park |
Sunday 13 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 |  Twente vs Sparta Rotterdam | - | Eredivisie Stage : MD16 | De Grolsch Veste |
Thursday 17 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 21h00 |  Twente vs Kairat Almaty | - | UEFA Conference League Stage : League phase Matchday 6 | De Grolsch Veste |
Sunday 20 December
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 |  Feyenoord vs Twente | - | Eredivisie Stage : MD17 | De Kuip |
Friday 8 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | Twente vs Fortuna Sittard | - | Eredivisie Stage : MD18 | De Grolsch Veste |
Sunday 17 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 12h15 | Utrecht vs Twente | - | Eredivisie Stage : MD19 | Stadion Galgenwaard |
Saturday 23 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 20h00 | Twente vs Heerenveen | - | Eredivisie Stage : MD20 | De Grolsch Veste |
Sunday 31 January
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 14h30 | Twente vs Cambuur | - | Eredivisie Stage : MD21 | De Grolsch Veste |
Sunday 14 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | PSV Eindhoven vs Twente | - | Eredivisie Stage : MD22 | Philips Stadion |
Sunday 21 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Twente vs Excelsior | - | Eredivisie Stage : MD23 | De Grolsch Veste |
Sunday 28 February
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | ADO Den Haag vs Twente | - | Eredivisie Stage : MD24 | WerkTalent Stadion |
Sunday 7 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Twente vs AZ Alkmaar | - | Eredivisie Stage : MD25 | De Grolsch Veste |
Sunday 14 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Willem II vs Twente | - | Eredivisie Stage : MD26 | Koning Willem II Stadion |
Sunday 21 March
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 17h00 | Twente vs GO Ahead Eagles | - | Eredivisie Stage : MD27 | De Grolsch Veste |
Sunday 4 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Ajax vs Twente | - | Eredivisie Stage : MD28 | Johan Cruijff Arena |
Sunday 11 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Telstar vs Twente | - | Eredivisie Stage : MD29 | BUKO Stadion |
Sunday 25 April
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Twente vs NEC Nijmegen | - | Eredivisie Stage : MD30 | De Grolsch Veste |
Sunday 2 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Sparta Rotterdam vs Twente | - | Eredivisie Stage : MD31 | Sparta Stadion Het Kasteel |
Sunday 9 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 16h00 | Twente vs Groningen | - | Eredivisie Stage : MD32 | De Grolsch Veste |
Sunday 16 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 | Twente vs Feyenoord | - | Eredivisie Stage : MD33 | De Grolsch Veste |
Sunday 23 May
| Time | Match | Score | Competition | Stadium |
|---|---|---|---|---|
| 13h30 | PEC Zwolle vs Twente | - | Eredivisie Stage : MD34 | - |