| 25/07/2026 |   Quindio vs Popayan | 21h00 | Primera B
Phase : Clausura J1 | 2026 | Stade Centenario |
| 01/08/2026 |  Popayan vs Tigres FC | 21h00 | Primera B
Phase : Clausura J2 | 2026 | - |
| 04/08/2026 |  Real Soacha vs Popayan | 21h00 | Primera B
Phase : Clausura J3 | 2026 | Stade Municipal de Mosquera |
| 08/08/2026 |  Popayan vs Union Magdalena | 21h00 | Primera B
Phase : Clausura J4 | 2026 | - |
| 15/08/2026 |  Orsomarso vs Popayan | 21h00 | Primera B
Phase : Clausura J5 | 2026 | Stade Daniel Villa Zapata |
| 22/08/2026 |  Popayan vs Bogota FC | 21h00 | Primera B
Phase : Clausura J6 | 2026 | - |
| 29/08/2026 |  Barranquilla vs Popayan | 21h00 | Primera B
Phase : Clausura J7 | 2026 | Stade Romelio Martinez |
| 05/09/2026 |  Popayan vs Envigado | 21h00 | Primera B
Phase : Clausura J8 | 2026 | - |
| 12/09/2026 |  Popayan vs Real Santander | 21h00 | Primera B
Phase : Clausura J9 | 2026 | - |
| 19/09/2026 |  Leones FC vs Popayan | 21h00 | Primera B
Phase : Clausura J10 | 2026 | Stade Metropolitano Ciudad de Itagui |
| 26/09/2026 |  Popayan vs Patriotas | 21h00 | Primera B
Phase : Clausura J11 | 2026 | - |
| 03/10/2026 |  Real Cartagena vs Popayan | 21h00 | Primera B
Phase : Clausura J12 | 2026 | - |
| 07/10/2026 |  Popayan vs Depor FC | 21h00 | Primera B
Phase : Clausura J13 | 2026 | - |
| 10/10/2026 |  Ind. Yumbo vs Popayan | 21h00 | Primera B
Phase : Clausura J14 | 2026 | Stade Municipal Raul Miranda |
| 17/10/2026 |  Popayan vs Internacional Palmira | 21h00 | Primera B
Phase : Clausura J15 | 2026 | - |
