| 00:30 | Inter Miami  | 7 - 1 |  CF Montreal | Major League Soccer
Phase : J22 | Stade Nu |
| 00:30 | DC United  | 0 - 0 |  Los Angeles FC | Major League Soccer
Phase : J22 | Audi Field |
| 00:30 | New York Red Bulls  | 1 - 3 |  Philadelphia Union | Major League Soccer
Phase : J22 | Stade Sports Illustrated |
| 00:30 | Toronto FC  | 1 - 1 |  New York City FC | Major League Soccer
Phase : J22 | BMO Field |
| 00:30 | Atlanta United FC  | 0 - 2 |  Charlotte | Major League Soccer
Phase : J22 | Stade Mercedes-Benz |
| 01:30 | Nashville SC  | 4 - 0 |  FC Cincinnati | Major League Soccer
Phase : J22 | Geodis Park |
| 01:30 | Sporting Kansas City  | 0 - 3 |  Vancouver Whitecaps | Major League Soccer
Phase : J22 | Children's Mercy Park |
| 01:30 | Minnesota United FC  | 3 - 3 |  Orlando City SC | Major League Soccer
Phase : J22 | Allianz Field |
| 01:30 | Houston Dynamo  | 0 - 0 |  San Jose Earthquakes | Major League Soccer
Phase : J22 | Stade Shell Energy |
| 02:30 | Colorado Rapids  | 1 - 0 |  Real Salt Lake | Major League Soccer
Phase : J22 | Dick's Sporting Goods Park |
| 03:30 | San Diego  | 3 - 1 |  Los Angeles Galaxy | Major League Soccer
Phase : J22 | Stade Snapdragon |
| 03:30 | Portland Timbers  | 1 - 2 |  Austin | Major League Soccer
Phase : J22 | Providence Park |
| 11:00 | Amarante  | 1 - 0 |  Benfica B | Segunda Liga
Phase : J4 | Stade Amarante |
| 11:00 | Machico  | 2 - 2 |  Camacha | Taça de Portugal
Phase : 1/128-finals | - |
| 12:30 | SV Darmstadt 98  | 0 - 1 |  Hannover 96 | 2. Bundesliga
Phase : J3 | Merck-Stadion am Bollenfalltor |
| 12:30 | 1. FC Magdeburg  | 2 - 0 |  Holstein Kiel | 2. Bundesliga
Phase : J3 | Arène Avnet |
| 12:30 | FC St. Pauli  | 1 - 2 |  1. FC Kaiserslautern | 2. Bundesliga
Phase : J3 | Millerntor-Stadion |
| 14:00 | AFC Wimbledon  | 1 - 0 |  Wigan | League One
Phase : J3 | Stade The Cherry Red Records |
| 14:00 | Paris FC  | 3 - 0 |  Nice | Ligue 1
Phase : J2 | Stade Jean Bouin |
| 14:00 | Chelsea  | 4 - 3 |  Brighton | Premier League
Phase : J2 | Stamford Bridge |
| 14:00 | Leeds  | 1 - 1 |  Brentford | Premier League
Phase : J2 | Elland Road |
| 14:00 | Sunderland  | 1 - 0 |  Fulham | Premier League
Phase : J2 | Stadium of Light |
| 14:00 | AVS  | 2 - 0 |  Feirense | Segunda Liga
Phase : J4 | Stade do CD das Aves |
| 14:00 | Portalegrense  | 0 - 3 |  Santo Antonio | Taça de Portugal
Phase : 1/128-finals | - |
| 14:30 | SC Freiburg  | 4 - 1 |  Werder Bremen | Bundesliga
Phase : J1 | Europa-Park Stadion |
| 15:00 | Mansfield Town  | 5 - 2 |  Luton | League One
Phase : J3 | Stade One Call |
| 15:15 | Al Mesaimeer  | 1 - 2 |  UMM Salal | Second Division
Phase : J2 | Stade Al Seliah |
| 15:30 | Nacional  | 2 - 3 |  Estrela | Primeira Liga
Phase : J4 | Estádio da Madeira |
| 16:00 | Real Madrid  | 4 - 0 |  Malaga | La Liga
Phase : J3 | Bernabéu |
| 16:00 | FC Andorra  | 0 - 1 |  Eibar | Segunda División
Phase : J3 | Estadi de la FAF |
| 16:00 | Montalegre  | - |  Ponte da Barca | Taça de Portugal
Phase : 1/128-finals | - |
| 16:15 | Rennes  | 3 - 2 |  Le Mans | Ligue 1
Phase : J2 | Roazhon Park |
| 16:30 | FC Augsburg  | 3 - 0 |  FC Schalke 04 | Bundesliga
Phase : J1 | Arène WWK |
| 16:30 | ES Sahel  | 2 - 1 |  ES Metlaoui | Ligue 1
Phase : J2 | Stade Olympique de Sousse |
| 16:30 | CS Hammam-Lif  | 0 - 1 |  CA Bizertin | Ligue 1
Phase : J2 | Stade Municipal de Hammam-Lif |
| 16:30 | Jeunesse Sportive Omrane  | 3 - 1 |  ES Tunis | Ligue 1
Phase : J2 | Stade Chedly Zouiten |
| 16:30 | Olympique Béja  | 1 - 2 |  US Ben Guerdane | Ligue 1
Phase : J2 | Stade Boujemaa Kmiti |
| 16:30 | Manchester United  | 5 - 2 |  Ipswich | Premier League
Phase : J2 | Old Trafford |
| 17:00 | Esenler Erokspor  | 0 - 1 |  Iğdır FK | 1. Lig
Phase : J4 | Stade Esenler |
| 17:00 | Eyüpspor  | 2 - 1 |  Alanyaspor | Süper Lig
Phase : J3 | Stade Recep Tayyip Erdogan |
| 17:00 | Académico do Fundão  | - |  Guarda | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Alcains  | - |  Sertanense | Taça de Portugal
Phase : 1/128-finals | Estádio Trigueiros do Aragão |
| 17:00 | Celoricense  | - |  Pevidem | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | CF Benfica  | - |  Viana Alentejo | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Cinfães  | - |  Espinho | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | SC Covilha  | - |  Mortágua | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Mação  | - |  Gavionenses | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Maria da Fonte  | - |  Uniao Nogueirense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Messejanense  | - |  Portel | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Nazarenos  | - |  Vitória de Sernache | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Oliveira Hospital  | - |  Sourense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Rebordosa  | - |  Alpendorada | Taça de Portugal
Phase : 1/128-finals | Complexo Desportivo Azevido |
| 17:00 | Régua  | - |  AD Marco 09 | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Sanjoanense  | - |  Pacos de Brandao | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Vianense  | - |  Minas de Argozelo | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | UD da Serra  | - |  Uniao de Pombal | Taça de Portugal
Phase : 1/128-finals | Campo da Portela |
| 17:00 | 1º Dezembro  | - |  Real | Taça de Portugal
Phase : 1/128-finals | Campo Conde de Sucena |
| 17:00 | Caldas  | 1 - 3 |  Sintrense | Taça de Portugal
Phase : 1/128-finals | Campo da Mata |
| 17:00 | Castrense  | 0 - 1 |  Louletano | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Correlhã  | 1 - 4 |  Os Limianos | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Ermesinde  | 1 - 3 |  Paredes | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Fazendense  | 1 - 0 |  Mocarriense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Ferreiras  | 0 - 3 |  Aljustrelense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Florgrade  | 0 - 0 |  São João Ver | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | AD Fornos Algodres  | 0 - 4 |  Os Marialvas | Taça de Portugal
Phase : 1/128-finals | Estádio Municipal Serra da Esgalhada |
| 17:00 | Lusitano Évora 1911  | 1 - 2 |  CF Os Belenenses | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Maia Lidador  | 0 - 0 |  Vila Meã | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Merelinense  | 2 - 0 |  Atlético Arcos | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | AD Nogueirense  | 1 - 3 |  Naval 1893 | Taça de Portugal
Phase : 1/128-finals | Estádio Santo António |
| 17:00 | Rebordelo  | 0 - 4 |  Bragança | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Salgueiros  | 2 - 1 |  Sousense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | União Montemor  | 1 - 4 |  Juventude Évora | Taça de Portugal
Phase : 1/128-finals | - |
| 17:00 | Sacavenense  | 5 - 0 |  Angrense | Taça de Portugal
Phase : 1/128-finals | - |
| 17:05 | Al-Hazm  | 1 - 1 |  Al Shabab | Pro League
Phase : J4 | Stade Al-Hazem Club |
| 17:30 | Al-Gharafa B  | 0 - 3 |  Al-Markhiya | Second Division
Phase : J2 | - |
| 17:30 | Al Kharaitiyat  | 3 - 1 |  Al-Khor | Second Division
Phase : J2 | Stade Al Khor |
| 17:30 | Napoli  | 1 - 2 |  Como | Serie A
Phase : J2 | Stadio Diego Armando Maradona |
| 18:00 | Casa Pia  | 0 - 1 |  Moreirense | Primeira Liga
Phase : J4 | Estádio Municipal de Rio Maior |
| 18:00 | Cadiz  | 1 - 1 |  Valladolid | Segunda División
Phase : J3 | Nuevo Mirandilla |
| 18:00 | Mallorca  | 3 - 0 |  AD Ceuta FC | Segunda División
Phase : J3 | Estadi Mallorca Son Moix |
| 18:00 | FC Porto B  | 0 - 3 |  Penafiel | Segunda Liga
Phase : J4 | Stade Luis Filipe Menezes |
| 18:00 | Felgueiras 1932  | 2 - 1 |  Chaves | Segunda Liga
Phase : J4 | Estádio Dr. Machado de Matos |
| 18:00 | Sporting CP B  | 2 - 1 |  Farense | Segunda Liga
Phase : J4 | CGD Stadium Aurelio Pereira |
| 18:00 | Arezzo  | 2 - 3 |  Palermo | Serie B
Phase : J2 | Stadio Città di Arezzo |
| 18:00 | Mantova  | 3 - 1 |  Empoli | Serie B
Phase : J2 | Stadio Danilo Martelli |
| 18:00 | SC Barreiro  | - |  Madalena | Taça de Portugal
Phase : 1/128-finals | - |
| 18:30 | Deportivo La Coruna  | 3 - 1 |  Valencia | La Liga
Phase : J3 | Stade Riazor |
| 19:00 | Al-Qadisiyah FC  | 3 - 1 |  Al-Faisaly FC | Pro League
Phase : J4 | Stade Prince Saud bin Jalawi |
| 19:30 | Manisa F.K.  | 0 - 0 |  Bodrum FK | 1. Lig
Phase : J4 | Mumin Ozkasap Spor Tesisleri |
| 19:30 | Başakşehir  | 1 - 1 |  Kasımpaşa | Süper Lig
Phase : J3 | Stade Basaksehir Fatih Terim |
| 19:30 | Samsunspor  | 0 - 2 |  Fenerbahçe | Süper Lig
Phase : J3 | Samsun Yeni 19 Mayıs Stadyumu |
| 19:45 | Monaco  | 2 - 0 |  Marseille | Ligue 1
Phase : J2 | Stade Louis II |
| 19:45 | Cagliari  | 0 - 1 |  Inter | Serie A
Phase : J2 | Unipol Domus |
| 19:45 | Lazio  | 1 - 0 |  Genoa | Serie A
Phase : J2 | Stadio Olimpico |
| 20:00 | Benevento  | 1 - 1 |  Sudtirol | Serie B
Phase : J2 | Stadio Ciro Vigorito |
| 20:00 | Pisa  | 2 - 1 |  Catanzaro | Serie B
Phase : J2 | Arena Garibaldi - Stadio Romeo Anconetani |
| 20:30 | Celta Vigo  | 0 - 2 |  Athletic Club | La Liga
Phase : J3 | Stade Abanca Balaídos |
| 20:30 | Famalicao  | 0 - 0 |  GIL Vicente | Primeira Liga
Phase : J4 | Estádio Municipal de Famalicão |
| 20:30 | Cordoba  | 1 - 3 |  Granada CF | Segunda División
Phase : J3 | Stade Nuevo Arcángel |
| 21:30 | Columbus Crew  | 1 - 3 |  New England Revolution | Major League Soccer
Phase : J22 | Lower.com Field |
FC Dallas
National Bank of Egypt
Al Rayyan SC B
AS Roma
Qatar U23
Al Waab
Real Sociedad II
Pyramids FC
Petrojet
Getafe
Çorum FK
Trabzonspor
