Sunday 22 February
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 4h30 |   San Jose Earthquakes vs Sporting Kansas City | 3 - 0 | Major League Soccer Phase : J1 | PayPal Park |
Sunday 1 March
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 |  San Jose Earthquakes vs Atlanta United FC | 2 - 0 | Major League Soccer Phase : J2 | PayPal Park |
Sunday 8 March
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 |  Philadelphia Union vs San Jose Earthquakes | 0 - 1 | Major League Soccer Phase : J3 | Subaru Park |
Monday 16 March
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 0h00 |  San Jose Earthquakes vs Seattle Sounders | 0 - 1 | Major League Soccer Phase : J4 | PayPal Park |
Sunday 22 March
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  Vancouver Whitecaps vs San Jose Earthquakes | 0 - 1 | Major League Soccer Phase : J5 | BC Place |
Sunday 5 April
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs San Diego | 3 - 0 | Major League Soccer Phase : J6 | PayPal Park |
Sunday 12 April
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 | Sporting Kansas City vs San Jose Earthquakes | 1 - 3 | Major League Soccer Phase : J7 | Children's Mercy Park |
Monday 20 April
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 0h00 |  Los Angeles FC vs San Jose Earthquakes | 1 - 4 | Major League Soccer Phase : J8 | Stade BMO |
Thursday 23 April
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs Austin | 5 - 1 | Major League Soccer Phase : J9 | PayPal Park |
Sunday 26 April
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 |  St. Louis City vs San Jose Earthquakes | 2 - 3 | Major League Soccer Phase : J10 | CITYPARK |
Saturday 2 May
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 18h00 |  Toronto FC vs San Jose Earthquakes | 1 - 1 | Major League Soccer Phase : J11 | BMO Field |
Sunday 10 May
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Jose Earthquakes vs Vancouver Whitecaps | 1 - 1 | Major League Soccer Phase : J12 | PayPal Park |
Thursday 14 May
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 2h30 | Seattle Sounders vs San Jose Earthquakes | 3 - 2 | Major League Soccer Phase : J13 | Lumen Field |
Sunday 17 May
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs FC Dallas | 2 - 3 | Major League Soccer Phase : J14 | PayPal Park |
Sunday 24 May
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 2h30 |  Portland Timbers vs San Jose Earthquakes | 1 - 3 | Major League Soccer Phase : J15 | Providence Park |
Thursday 23 July
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs Orlando City SC | 0 - 4 | Major League Soccer Phase : J16 | PayPal Park |
Sunday 26 July
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs Los Angeles Galaxy | 1 - 1 | Major League Soccer Phase : J17 | Stade Stanford |
Sunday 2 August
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 0h30 |  FC Cincinnati vs San Jose Earthquakes | - | Major League Soccer Phase : J18 | Stade TQL |
Sunday 16 August
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Jose Earthquakes vs St. Louis City | - | Major League Soccer Phase : J19 | PayPal Park |
Thursday 20 August
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | Los Angeles Galaxy vs San Jose Earthquakes | - | Major League Soccer Phase : J20 | Dignity Health Sports Park |
Sunday 23 August
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs Minnesota United FC | - | Major League Soccer Phase : J21 | PayPal Park |
Sunday 30 August
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 |  Houston Dynamo vs San Jose Earthquakes | - | Major League Soccer Phase : J22 | Stade Shell Energy |
Sunday 6 September
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 | Austin vs San Jose Earthquakes | - | Major League Soccer Phase : J23 | Stade Q2 |
Thursday 10 September
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Diego vs San Jose Earthquakes | - | Major League Soccer Phase : J24 | Stade Snapdragon |
Sunday 13 September
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Jose Earthquakes vs Houston Dynamo | - | Major League Soccer Phase : J25 | PayPal Park |
Sunday 20 September
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 0h30 | San Jose Earthquakes vs Los Angeles FC | - | Major League Soccer Phase : J26 | PayPal Park |
Sunday 27 September
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Jose Earthquakes vs Portland Timbers | - | Major League Soccer Phase : J27 | PayPal Park |
Sunday 11 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 2h30 |  Colorado Rapids vs San Jose Earthquakes | - | Major League Soccer Phase : J28 | Dick's Sporting Goods Park |
Thursday 15 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 2h30 |  Real Salt Lake vs San Jose Earthquakes | - | Major League Soccer Phase : J29 | America First Field |
Sunday 18 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 |  San Jose Earthquakes vs Nashville SC | - | Major League Soccer Phase : J30 | PayPal Park |
Sunday 25 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h30 | FC Dallas vs San Jose Earthquakes | - | Major League Soccer Phase : J31 | Stade Toyota |
Thursday 29 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 3h30 | San Jose Earthquakes vs Colorado Rapids | - | Major League Soccer Phase : J32 | PayPal Park |
Saturday 31 October
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 22h00 | San Jose Earthquakes vs Real Salt Lake | - | Major League Soccer Phase : J33 | PayPal Park |
Sunday 8 November
| Heure | Match | Score | Compétition | Stade |
|---|---|---|---|---|
| 1h00 | Minnesota United FC vs San Jose Earthquakes | - | Major League Soccer Phase : J34 | Allianz Field |